Proponents of legalizing prostitution believe it would reduce crime, improve public health, increase tax revenue, help people out of poverty, get prostitutes off the streets, and allow consenting adults to make their own choices. They contend that prostitution is a victimless crime, especially in the 11 Nevada counties where it remains legal.

Opponents believe that legalizing prostitution would lead to increases in sexually transmitted diseases such as AIDS, global human trafficking, and violent crime including rape and homicide. They contend that prostitution is inherently immoral, commercially exploitative, empowers the criminal underworld, and promotes the repression of women by men.